Clinical trials and safety studies have
been completed, but have not been submitted for publication.
Since DGP itself is new, and many of its natural constituents
may not be known to pet owners or veterinarians, here
is list of ingredients and relevant research.
- tanacetum parthenium is a relative of the common daisy,
found originally in Europe and spread throughout the
world by deliberate planting. It's been widely used
in herbal medicine since the time of the ancient Greeks
to calm hysteria, control inflammation and reduce pain,
particularly migraine headaches. Modern research confirms
that Tanacetum parthenium is a serotonin antagonist,
which account for its calming effects, suppresses leukotriene
release by basophils, mast cells, macrophages and lung
tissue that participate in allergic reaction, and lowers
the production of thromboxanes by patelets which inhibits
vascular and bronchial smooth muscle contractions and
Research has shown it to be non-toxic, but because of
its effect on platelet aggregation, which can increse
blood clotting time, caution should be used when combining
it with anti-clotting drugs.
Seed - Apium graveolenes, grown throughout
the world, is used widely in herbal medicine and foods,
and is listed by the FDA as GRAS. In herbal medicine
it is used for rheumatism, arthritis, gout, fluid retention,
and to calm digestion and stimulate digestion appetite.
Medical and scientific research confirm the safety of
Apium graveolens and show it provides potent anti-flammatory
effects, reduces uric acid in the blood and aids liver
function by protecting liver cells from chemical toxins
and lowering cholesterol.
Serrata, also known as Frankicense, has long
been used in European and Indian herbal medicine as
an anti-inflammatory and analgesic. Recent research
shows benefits in osteo and rheumatoid arthritis, asthma
and ulcerative colitis. Studies are underway for its
use in the treatment of gliomas and other cancers. It
has been shown to block the production of pro-inflammatory
leukotrienes, but unlike other NSAIDs, it does not disrupt
glycosaminoglycan synthesis which can accelerate damage
to cartilage. Research shows that it is non-toxic and
no adverse events have been reported.
is a mixture of protein-digesting enzymes made from
the stem of the pineapple, Ananas comosus, and is listed
by the FDA as GRAS. It is used for digestive disorders
and a wide range of conditions associated with inflammation
caused by infection or injury. Animal and human research
show that it modulates inflammation by preventing the
build up of bradykinins and kallidins that cause swelling
and helps speed up wound healing related to surgery
Toxicity studies show that it is safe, but it has been
shown to enhance absorption of antibiotics and anticoalulants
and should be used with caution combined with these
is a protein digesting enzyme derived from the milky
sap of unripe papaya, Carica papaya. It is cultivated
in Australia and tropical region throughout the world
and used in cooking as a meat tenderizer and an herbal
treatment to aid digestion, combat intestinal parasites.
Research shows that it is non-toxic and it is listed
by the FDA as GRAS.
Root, Corydalis turtschaninovii, is an herb
that originated in China and is cultivated throughout
the Pacific Rim. It is used in traditional medicince
as a tonic for the circulatory system, and for its pain
relieving and calming effects. Scientist have isolated
a number of active ingredients that show a wide range
of actions on the nervous system. In human research,
a double-blind study showed that heart arrhythmia patients
exhibited significant improvement.
Other studies showed improvement in sleep in insomnia
patients without sedative like side effects, and showed
it was effective reducing nerve pain, and pain from
dysmeorrheal and headache. Toxicity studies show that
it is an exceptionally safe herb, no adverse events
have been reported, and no herb-drug interactions are
Capsicum frutescens, is red-pepper used commonly in
many of the world's culinary and medicinal traditions
and is listed by the FDA as GRAS. Studies of traditional
use in ethnic groups around the world show associated
benefits in terms of the gastrointestinal health, thermoregulation
and nutritional uptake. Analysis of its constituents,
reveal many active dietary phytochemicals that exhibit
potent anti-viral, antibacterial, anti-mutagenic and
Human studies show that oral use decreased appetite
and subsequent protein and fat intake, and stimulated
carbohydrate metabolism at rest or during exercise.
All adverse events relate to external use in pepper
spray and accidental over exposure to the skin, none
due to ingestion, and not herb-drug interactions.
Triticum aestivum, is common wheat harvested in the
sprouting stage at seven days of growth. It is a concentrated
food source, rich in cholophyll, amylase, lipase, superoxide
dismutase and other enzymes, iron, calcium, magnesium,
potassium and more than 80 minerals, 18 amino acids,
beta carotene and many vitamins. It has been widely
used since the 1930's when U.S. research showed that
it was benefial as a dietary supplement for animals.
There have been no reports of side-effects or interference
with any drugs, and not contraindications.
Curcuma longa L, native of India and grown throughout
the Pacific, has long been used as a spice and medicinal
herb as a digestive aid, for fever, infection dysentery,
arthritis, jaundice, liver and gall bladder problems.
In terms of modern research, there are more than 100
published peer-review studies on this herb, establishing
tumeric's hepatoprotective, anti-inflammatory, anti-carcinogenic,
and antimicrobial properties, and its use in cardiovascular
disease, gastrointestinal disorders and to speed wound
Many of these benefits are attributed to its anti-inflammatory
activity resulting form the down regulation of COX-2
enzymes and the cytokines TNF and IL-1, and its antioxidant
activity that supports higher activity of the enzymes
superoxide dismutase, catalase and glutathinone peroxidase,
demonstrated to protect hemogoblin from oxidation and
inhibit lipid perioxidation. These mechanisms have also
demostrated nemetocidal anti-protozoal, anti-bacterial
activity, anti-viral and anti-tumor activity. It is
listed by the FDA as GRAS.
Shark cartilage is the skeletal material
of shark and has been consumed as a health food in traditional
Chinese medicine for its broad anti-aging benefits.
Recent scientific studies have confirmed it benefits
for the treatment and prevention of degenerative joint
disease. It is an excellent dietary source of chondroitin
sulfate and other glycoaminoglycans that rebuild cartilage,
and calcium, magnesium, phosphorus, zinc and other bone
No sharks are caught in the manufacture of this product,
the sharks used are harvested for sale as seafood, the
cartilage is a by-product. Toxicity studies have shown
it to be safe and non-toxic at all but extremely high